SPCG-4
Expectation or radical prostatectomy on early prostate cancer
Randomized clinical trial of radical prostatectomy versus watchful waiting
22 publications
Publications of the SPCG-4 trial
Inguinal hernia after radical prostatectomy for prostate cancer: results from a randomized setting and a nonrandomized setting
Stranne J, Johansson E, Nilsson A, Bill-Axelsson A, Carlsson S, Holmberg L, Johansson JE, Nyberg T, Ruutu M, Wiklund NP, Steineck G
Eur Urol. 2010
Time, symptom burden, androgen deprivation, and self-assessed quality of life after radical prostatectomy or watchful waiting: The randomized Scandinavian Prostate Cancer Group study number 4
Johansson E, Bill-Axelson A, Holmberg L, Onelöv E, Johansson J-E, Steineck G
Eur Urol. 2009
Experiences of randomization: Interviews with patients and clinicians in the SPCG-IV trial
Bill-Axelson A, Christensson A, Carlsson M, Norlén BJ, Holmberg L
Scand J Urol Nephrol. 2008
Radical Prostatectomy Versus Watchful Waiting in Localized Prostate Cancer: the Scandinavian Prostate Cancer Group-4 Randomized Trial
Bill-Axelson A, Holmberg L, Filén F, Ruutu M, Garmo H, Busch C, Nordling S, Häggman M, Andersson SO, Bratell S, Spångberg A, Palmgren J, Adami HO, Johansson JE
J Natl Cancer Inst. 2008
Prostate-specifik antigen levels as a predictor of lethal prostate cancer
Fall K, Garmo H, Andrén O, Bill-Axelson, Adolfsson J, Adami H-O,Johansson J-E, Holmberg L
J Natl Cancer Inst. 2007
Prognostic markers under watchful waiting and radical prostatectomy
Holmberg L, bill-Axelson A, Garmo H, Palmgren J, Norlén HB, Adami H-O, Johansson J-E
Hematol Oncol Clin North Am. 2006
Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer
Bill-Axelson A1, Holmberg L, Ruutu M, Häggman M, Andersson SO, Bratell S, Spångberg A, Busch C, Nordling S, Garmo H, Palmgren J, Adami HO, Norlén BJ, Johansson JE; Scandinavian Prostate Cancer Group Study No. 4.
N Engl J Med. 2005
Quality of life after radical prostatectomy or watchful waiting
Steineck G, Helgesen F, Adolfsson J, Dickman PW, Johansson J-E, Norlén BJ, Holmberg L
N Engl J Med. 2002
A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer
Holmberg L, Bill-Axelson A, Helgesen F, Salo JO, Folmerz P, Häggman M, Andersson S-O, Spångberg A, Busch C, Nordling S, Palmgren J, Adami H-O, Johansson J-E, Norlén BJ
N Engl J Med. 2002
Time depencence of outcomes in the SPCG-4 randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer
Lars Holmberg, Hans Garmo, Sven-Olov Andersson, Ove Andrén, Eva Johansson, Kimmo Taari, Michael Häggman, Stig Nordling, Hans-Olov Adami, Anna Bill-Axelson
Eur Urol . 2025
Time without PSA recurrence after radical prostatectomy as a predictor of future biochemical recurrence, metastatic disease and prostate cancer death: a prospective Scandinavian cohort study
Mats Steinholtz Ahlberg , Hans Garmo , Hans-Olov Adami , Ove Andrén , Jan-Erik Johansson , Gunnar Steineck , Lars Holmberg , Anna Bill-Axelson
BMJ Open
Impact of cancer screening on metastasis: A prostate cancer case study
Jane Lange, Sebastiaan Remmers, Roman Gulati, Anna Bill-Axelson, Jan-Erik Johansson, Maciej Kwiatkowski, Anssi Auvinen, Jonas Hugosson, Jim C Hu, Monique J Roobol, Sigrid V Carlsson, Ruth Etzioni
J Med Screen . 2021
Prostate cancer mortality and metastasis under different biopsy frequencies in North American active surveillance cohorts
Jane M Lange, Aaron A Laviana, David F Penson, Daniel W Lin, Anna Bill-Axelson, Sigrid V Carlsson, Lisa F Newcomb, Bruce J Trock, H Ballentine Carter, Peter R Carroll, Mathew R Cooperberg, Janet E Cowan, Laurence H Klotz, Ruth B Etzioni
Cancer . 2020
Mortality after radical prostatectomy in a matched contemporary cohort in Sweden compared to the Scandinavian Prostate Cancer Group 4 (SPCG-4) study
Walter Cazzaniga, Hans Garmo, David Robinson, Lars Holmberg, Anna Bill-Axelson, Pär Stattin
BJU Int . 2019
Radical prostatectomy versus watchful waiting in early prostate cancer
Anna Bill-Axelson, Lars Holmberg, Mirja Ruutu, Hans Garmo, Jennifer R Stark, Christer Busch, Stig Nordling, Michael Häggman, Swen-Olof Andersson, Stefan Bratell, Anders Spångberg, Juni Palmgren, Gunnar Steineck, Hans-Olov Adami, Jan-Erik Johansson; SPCG-4 Investigators
N Engl J Med . 2011
Radical prostatectomy or watchful waiting in early prostate cancer.
Bill-Axelson A, Holmberg L, Garmo H, Rider JR, Taari K, Busch C, Nordling S, Häggman M, Andersson SO, Spångberg A, Andrén O, Palmgren J, Steineck G, Adami HO, Johansson JE.
N Engl J Med. 2014
Long-term distress after radical prostatectomy versus watchful waiting in prostate cancer: a longitudinal study from the Scandinavian Prostate Cancer Group-4 randomized clinical trial.
Bill-Axelson A, Garmo H, Holmberg L, Johansson JE, Adami HO, Steineck G, Johansson E, Rider JR.
Eur Urol. 2013
Results from the Scandinavian Prostate Cancer Group Trial Number 4: A randomized controlled trial of radical prostatectomy versus watchful waiting.
Holmberg L, Bill-Axelson A, Steineck G, Garmo H, Palmgren J, Johansson E, Adami HO, Johansson JE.
J Natl Cancer Inst Monogr. 2012
Individualized estimation of the benefit of radical prostatectomy from the Scandinavian Prostate Cancer Group randomized trial
Andrew Vickers, Caroline Bennette, Gunnar Steineck, Hans-Olov Adami, Jan-Erik Johansson, Anna Bill-Axelson, Juni Palmgren, Hans Garmo, Lars Holmberg
Eur Urol . 2012
Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
Eva Johansson, Gunnar Steineck, Lars Holmberg, Jan-Erik Johansson, Tommy Nyberg, Mirja Ruutu, Anna Bill-Axelson; SPCG-4 Investigators
Lancet Oncol . 2011
Development of a new method for monitoring prostate-specific antigen changes in men with localised prostate cancer: a comparison of observational cohorts
Kate Tilling, Hans Garmo, Chris Metcalfe, Lars Holmberg, Freddie C Hamdy, David E Neal, Jan Adolfsson, Richard M Martin, Michael Davis, Katja Fall, J Athene Lane, Hans-Olaf Adami, Anna Bill-Axelson, Jan-Eric Johansson, Jenny L Donovan
Eur Urol . 2010
Quality of Life after Radical Prostatectomy or Watchful Waiting With or Without Androgen Deprivation Therapy: The SPCG-4 Randomized Trial
Eva Johansson, Gunnar Steineck, Lars Holmberg, Jan-Erik Johansson, Tommy Nyberg, Anna Bill-Axelson; SPCG-4 Investigators
Eur Urol Oncol . 2018