SPCG-4

Expectation or radical prostatectomy on early prostate cancer

Randomized clinical trial of radical prostatectomy versus watchful waiting

Finished

SPCG-4 info

Principal investigator

Jan-Erik Johansson

Contact details

Patients

T0-2,Nx,M0,Gr1-2, age ≤ 75 years and expected survival ≥ 10 years

Treatment

Radical prostatectomy vs. expectants

Inclusion period

Sep. 1989–May 1999

Number of patients

693, 14 Centers

Sponsor

SPCG, Swedish Cancer Foundation

9 publications

Publications of the SPCG-4 trial

Inguinal hernia after radical prostatectomy for prostate cancer: results from a randomized setting and a nonrandomized setting

Stranne J, Johansson E, Nilsson A, Bill-Axelsson A, Carlsson S, Holmberg L, Johansson JE, Nyberg T, Ruutu M, Wiklund NP, Steineck G

Eur Urol. 2010

Abstract

Time, symptom burden, androgen deprivation, and self-assessed quality of life after radical prostatectomy or watchful waiting: The randomized Scandinavian Prostate Cancer Group study number 4

Johansson E, Bill-Axelson A, Holmberg L, Onelöv E, Johansson J-E, Steineck G

Eur Urol. 2009

Abstract

Experiences of randomization: Interviews with patients and clinicians in the SPCG-IV trial

Bill-Axelson A, Christensson A, Carlsson M, Norlén BJ, Holmberg L

Scand J Urol Nephrol. 2008

Abstract

Radical Prostatectomy Versus Watchful Waiting in Localized Prostate Cancer: the Scandinavian Prostate Cancer Group-4 Randomized Trial

Bill-Axelson A, Holmberg L, Filén F, Ruutu M, Garmo H, Busch C, Nordling S, Häggman M, Andersson SO, Bratell S, Spångberg A, Palmgren J, Adami HO, Johansson JE

J Natl Cancer Inst. 2008

Abstract

Prostate-specifik antigen levels as a predictor of lethal prostate cancer

Fall K, Garmo H, Andrén O, Bill-Axelson, Adolfsson J, Adami H-O,Johansson J-E, Holmberg L

J Natl Cancer Inst. 2007

Abstract

Prognostic markers under watchful waiting and radical prostatectomy

Holmberg L, bill-Axelson A, Garmo H, Palmgren J, Norlén HB, Adami H-O, Johansson J-E

Hematol Oncol Clin North Am. 2006

Abstract

Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer

Bill-Axelson A1, Holmberg L, Ruutu M, Häggman M, Andersson SO, Bratell S, Spångberg A, Busch C, Nordling S, Garmo H, Palmgren J, Adami HO, Norlén BJ, Johansson JE; Scandinavian Prostate Cancer Group Study No. 4.

N Engl J Med. 2005

Abstract

Quality of life after radical prostatectomy or watchful waiting

Steineck G, Helgesen F, Adolfsson J, Dickman PW, Johansson J-E, Norlén BJ, Holmberg L

N Engl J Med. 2002

Abstract

A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer

Holmberg L, Bill-Axelson A, Helgesen F, Salo JO, Folmerz P, Häggman M, Andersson S-O, Spångberg A, Busch C, Nordling S, Palmgren J, Adami H-O, Johansson J-E, Norlén BJ

N Engl J Med. 2002

Abstract